Cancer Treatment: Therapeutic approach gives hope for the treatment of multiple myeloma

March 10, 2016 - myleoma

Montreal, February 5, 2016 – A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.

The study was lead be Dr. Jean Roy, a haematologist at the Maisonneuve-Rosemont Hospital and professor at the University of Montreal, between 2001 and 2010 with 92 newly diagnosed patients. Using an approach developed at Maisonneuve-Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41%, a record level using this strategy. Moreover, patients in complete remission six months after the allograft had a relapse-free survival rate of 60%. Overall, the autograft strategy followed by allograft resulted in relapse-free survival rates of 20-25% in the long term.

“In many hospitals, doctors have abandoned the use of allografts for multiple myeloma due to the risk of toxicity and relapse. Our results, on the other hand, have led us to offer the treatment to more patients, especially younger patients and those with poorer prognoses,” said Dr. Roy.

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