Childhood Leukemia and Prevention
Sep 13 2019Cancer is the second most common cause of death in children 0–14 years of age, after accidents. Leukemia is the most common cancer in children, …
RESOURCES
Clinical Trials
Clinical research trials reveal new discoveries, uncover future treatments, and provide answers to our questions. This section of our resource center presents cancer-related trials on various types of cancer from medical institutions around the world.
ALL LATEST ENTRIES
Decrease in Specific Gene ‘Silencing’ Molecules Linked With Pediatric Brain Tumors
Nov 13 2018Johns Hopkins Medicine researchers have found that a shortage of specific tiny molecules that silence certain genes are linked to the development and growth of …
Cell Death-Based Treatment of Childhood Cancer
Sep 10 2018Any therapy that aims at eradicating a cancerous growth will have at its core a cell death-inducing component. Here we argue that paediatric oncology presents …
Diabetes Risk in Childhood Cancer Survivors
Sep 4 2018With continued improvements in survival following childhood cancer, the long-term health consequences of cancer treatments are receiving greater focus. Diabetes is emerging as a potential late effect of cancer therapy; however, the magnitude …
Brain Development and Heart Function After Systemic Single-agent Chemotherapy
Aug 21 2018Chemotherapy for childhood acute lymphoblastic leukemia (ALL) can cause late-appearing side effects in survivors that affect multiple organs, including the heart and brain. However, the complex ALL …
Recurrent Glioblastoma Treated with Recombinant Poliovirus
Jun 27 2018The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted …
Runx3 programs CD8+ T Cell Residency in Non-lymphoid Tissues and Tumours
Dec 1 2017Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses1,2. However, the molecular …
FDA Announces Approval, CMS Proposes Coverage of First Breakthrough-designated Test to Detect Extensive Number of Cancer Biomarkers
Nov 30 2017FDA approves test to detect mutations in 324 genes, two genomic signatures. Second to be approved with proposed coverage under FDA/CMS Parallel Review Program. The …
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Oct 4 2017Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition potently …
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