fbpx

Apoptosis-inducing Effects of Melissa Officinalis L. Essential Oil in Glioblastoma Multiforme Cells

March 22, 2016 -

Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation.

Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.

To learn more CLICK HERE.

CONTACT US

If you would like to speak to us about how you can become involved with our foundation, become a sponsored family, or just need general information, please submit the form below and one of our team members will contact you promptly.

FacebookTwitterPinterest